Author

Jack Chen

Frederick National Laboratory for Cancer ResearchPrimary ORCID profile (0000-0001-7528-4835 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Jack CheniD1 paper · University of Alaska Fairbanks

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 1 Assay:scRNA-seq· 1 Assay:structural biology· 1 Research Focus:variant calling· 1 Organism:virus· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alexander J. Hinbest· 1 shared Alexis Moreau· 1 shared Avinash BhandoolaiD· 1 shared Bao Tran· 1 shared Caiyi Li· 1 shared Castle Raley· 1 shared Cheryl Heiner· 1 shared Claudia Stewart· 1 shared

Activity by Year

2014-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperMicrobiology

Alexander J. Hinbest

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure of a key adhesin-exopolysaccharide interaction provides insights into matrix assembly in Vibrio cholerae biofilms

Alexander J. Hinbest, Hyerim Bianca Nam, Ewelina D. Liszczyk, Rajan Kandel, Emma Gerace, Alexis Moreau, Ranjuna Weerasekera, Ryan Gordon, Yiyan Yang, Jack Chen, Nathan Fowler, Xiaofang Jiang, Robert J. Woods, Jing Quan Yan, Rich Olson

This study determines the structure of Bap1 bound to VPS and shows how it facilitates biofilm adhesion and VPS organization through a conserved β-propeller interaction.

bioRxiv · Aug 4, 2026 · PreprintMicrobiology

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow

Jingxin Feng, Meiting Yang, Lili Li, Caiyi Li, Ferenc Livák, Jack Chen, Yongmei Zhao, Dunrui Wang, Avinash Bhandoola, Naomi N. Taylor, Giovanna Tosato

The paper identifies adult hemogenic endothelial cells in mouse bone marrow that generate hematopoietic stem/progenitor cells and functional blood cells.

eLife · Apr 27, 2026Peer-reviewedCell Biology

Preparation of next-generation DNA sequencing libraries from ultra-low amounts of input DNA: Application to single-molecule, real-time (SMRT) sequencing on the Pacific Biosciences RS II.

Castle Raley, David Munroe, Kristie Jones, Yu-Chih Tsai, Yan Guo, Bao Tran, Sujatha Gowda, Jennifer L. Troyer, Daniel R Soppet, Claudia Stewart, Robert Stephens, Jack Chen, TF Skelly, Cheryl Heiner, Jonas Korlach, Dwight Nissley

The paper develops an amplification-free method for preparing DNA sequencing libraries from very low DNA input for PacBio SMRT sequencing, achieving comparable yields with 1000-fold less starting material.

bioRxiv · Mar 25, 2014 · PreprintGenomics