FMR1 Perturbations Disrupt Sensory Corticostriatal Circuits and Mitochondrial Energetics in Fragile X Syndrome
Yu Yan, Dongyun Li, Jiangyu Yuan, Danyong Feng, Jiarui Chang, Fengyu Zhang, Man Xiong, Yan Jiang, Biao Yan, Qiong Xu, Rihui Li, Yi He, Peipei Liu, Mingshuo Shao, Minjie Shen
This study shows that FMR1 perturbations disrupt sensory corticostriatal circuits and mitochondrial function in FXS, with interventions improving social and cognitive deficits.
bioRxiv · Oct 11, 2026 · PreprintNeuroscience