Author

Yan Luo

Regenerative Immunotherapy & CAR-T Translational Research Program, Department of Cancer Biology, Mayo Clinic Jacksonville, FL, USA.;

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Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alfredo Quinones-Hinojosa· 1 shared Binyan Zhao· 1 shared Guangneng PengiD· 1 shared Haifeng LiuiD· 1 shared Hong Qin· 1 shared Hualin Fu· 1 shared Huan Liu· 1 shared James W Jakub· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMolecular Biology

Alfredo Quinones-Hinojosa

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Author profile →

3 papers

Recent·Most cited

A Standalone PD-1 Chimeric Switch Receptor T-Cell Platform Expands the Therapeutic Window of PD-L1 Targeting in Solid Tumors

Yan Luo, Shaohua Guo, Yaqing Qie, Binyan Zhao, Maria Jose Ulloa-Navas, Mieu Brooks, Vanessa Jones, Tanya Hundal, Julio C Chavez, Yanyan Lou, Loic Pierre Deleyrolle, Vamsidhar Velcheti, James W Jakub, Roxana Dronca, Mohamed A Kharfan-Dabaja, , Hong Qin

This paper develops a PD-1 chimeric switch receptor T-cell platform that improves tumor targeting while reducing toxicity to normal cells in PD-L1-targeted therapies.

bioRxiv · Nov 9, 2026 · PreprintMolecular Biology

Detection of Somatic Point Mutations Directly from Spatial Transcriptomics Enables in vivo Spatiotemporal Lineage Tracing

Zhirui Yang, Mengdie Yao, Qing Yang, Yiheng Du, Jinhong Lu, Xing Wu, Jinran Lin, Zhuoyu Qian, Song Hu, Yonghe Xia, Huan Liu, Qiji Zhou, Xiaoyu Ma, Yan Luo, Wenxuan Fan, , Yanmei Dou

SpaceTracer detects somatic SNVs from spatial transcriptomics data to enable lineage tracing in human tissues, revealing tumor progression and immune cell migration.

bioRxiv · Feb 6, 2026 · PreprintBioinformatics

First report and multilocus genotyping of Enterocytozoon bieneusi from Tibetan pigs in southwestern China

Run Luo, Leiqiong Xiang, Haifeng Liu, Zhijun Zhong, Li Liu, Lei Deng, Yuan Song, Ling Liu, Xiangming Huang, Ziyao Zhou, Hualin Fu, Yan Luo, Guangneng Peng

This study reports the prevalence and genetic diversity of E. bieneusi in Tibetan pigs, identifying novel genotypes and zoonotic potential.

Parasite · Jan 1, 2019Peer-reviewedGenetics