Loic P. Deleyrolle

This paper develops a PD-1 chimeric switch receptor T-cell platform that improves tumor targeting while reducing toxicity to normal cells in PD-L1-targeted therapies.

This study identifies cholesterol dependency as a therapeutic target in glioblastoma, showing that combined treatment with clemastine and bexarotene induces metabolic collapse and enhances antitumor immunity.

The paper identifies treatment-resistant persister cells in glioblastoma that exploit macrophage lipid metabolism to sustain tumor growth and immune evasion, suggesting lipid-targeted therapies could improve outcomes.

The paper introduces SNAQTM, an R Markdown script for analyzing spatial neighborhoods in immunohistochemical images to study tumor-immune interactions.

This study validates a murine model of glioblastoma stem cells that recapitulate human features and enables investigation of their interactions with the immune system.

This paper shows that combining Aurora Kinase A inhibition with Tumor Treating Fields reduces glioma cell proliferation, and this effect is not dependent on cilia.