Yang Shi

Nerve Injury-Induced Protein 2 Is Necessary for the Lysosome Membrane Integrity and Protects Cells from Ferroptosis

This study identifies NINJ2's role in maintaining lysosome membrane integrity and preventing ferroptosis by regulating iron homeostasis and ferritin stability.

Targeting SAGA/ATAC complexes disrupts chromatin regulation and cholesterol metabolism in diffuse midline glioma

This study shows that targeting SAGA/ATAC complexes disrupts chromatin regulation and cholesterol metabolism in diffuse midline glioma, leading to reduced tumor growth.

Elongin B orchestrates chromatin and transcriptional programs in H3K27M-mutant diffuse midline glioma

This study identifies elongin B as a key regulator of Pol2 elongation in H3K27M-mutant diffuse midline glioma, showing its role in maintaining chromatin and transcriptional dysregulation.

A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia

This paper shows that targeting STAT3 with a degrader can overcome Venetoclax resistance in AML by reducing MCL1 and improving mitochondrial function.

MCMC-CE: A Novel and Efficient Algorithm for Estimating Small Right-Tail Probabilities of Quadratic Forms with Applications in Genomics

The paper introduces MCMC-CE, an algorithm for estimating small right-tail probabilities of quadratic forms, showing improved accuracy and efficiency in genomics applications.

Differential Requirement of DICER1 Activity during Development of Mitral and Tricuspid Valves

The paper shows that DICER1 activity is essential for mitral valve development but not tricuspid valve development, revealing miRNA-mediated gene regulation as a differential mechanism.

Binding to m6A RNA promotes YTHDF2-mediated phase separation

This study shows that m6A RNA binding enables YTHDF2 and other m6A readers to undergo phase separation, which may regulate their localization in cells.