BioinformaticsbioRxivPreprint
Geometric-aware and interpretable deep learning for single-cell batch correction via explicit disentanglement and optimal transport
Chenghan Jiang, Ren Zheng, Yongle Ji…·Shuai Tao
iDLC corrects single-cell batch effects by explicitly disentangling biological and technical features and aligning distributions with geometric constraints, outperforming existing methods in preserving biological structure.