Genetic background and mistranslation frequency determine the impact of mistranslating tRNASerUGG
Matthew D. Berg, Yanrui Zhu, Raphaël Loll‐Krippleber…·Christopher J. Brandl
This study shows that the impact of a mistranslating tRNA variant depends on genetic background and mistranslation frequency in yeast, with implications for understanding tRNA variants in human disease.