Pharmacology & ToxicologybioRxivPreprint
PCO371 intracellular agonism at the parathyroid hormone 1 receptor produces pan-activation of signalling partners
Farhaan Napier Khwaja, Zamara Mariam, Yasaman Abdolhay…·Hoor Ayub
This study compares the functional and structural properties of the intracellular agonist PCO371 with the extracellular peptide agonist PTH 1-34 at the PTH1R, revealing PCO371's non-biased signaling profile and lower potency.
DOI 10.64898/2026.05.27.728112