BiochemistrybioRxivPreprint
Mechanism of phosphoinositide regulation of lysosomal pH via inhibition of CLC-7
Jacob K. Hilton, Yifei Lin, Eric Sefah…·Joseph A. Mindell
The paper investigates how PI(3,5)P2 regulates lysosomal pH by inhibiting ClC-7, showing structural changes in ClC-7 upon PI(3,5)P2 binding and linking this to disease mutations.
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