Cancer BiologybioRxivPreprint
Concurrent PIK3CA mutant drives cachexia through inflammatory signaling in EGFR mutant lung cancer
Meiting Yue, Zhen Qin, Shijie Tang…·Hongbin Ji
This study identifies PIK3CA mutations as drivers of cachexia in EGFR-mutant lung cancer, showing that osimertinib can mitigate cachexia but chemotherapy fails, with aspirin offering a potential treatment.
DOI 10.1101/2025.01.17.633515