BioinformaticsbioRxivPreprint
Cell DiffErential Expression by Pooling (CellDEEP) highlights issues in differential gene expression in scRNA-seq
Yiyi Cheng, Toby Kettlewell, Ross F Laidlaw…·Domenico Somma
CellDEEP improves differential gene expression analysis in scRNA-seq by aggregating cells into metacells, reducing false positives and increasing true positives compared to single-cell and pseudobulk methods.