Molecular BiologyNature CommunicationsPeer-reviewed
Global landscape of replicative DNA polymerase usage in the human genome
Eri Koyanagi, Yoko Kakimoto, Tamiko Minamisawa…·Yasukazu Daigaku
The paper uses Pu-seq to map DNA polymerase usage in human cells, revealing Polε synthesizes the leading strand and Pol contributes to lagging strand synthesis, and links transcription to polymerase uncoupling and chromosomal instability.
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