Molecular BiologybioRxivPreprint
Stromal CTHRC1 protects the valvular interstitium from macrophage-associated inflammatory remodeling and calcification
Hiroshi Sakamoto, Tomohisa Sakaue, Mika Hamaguchi…·Hironori Izutani
This study identifies CTHRC1 as a protective factor in valvular interstitium that limits macrophage-driven calcification in aortic valve disease.
DOI 10.64898/2026.09.21.753362