Author

Yuan Feng

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Pathology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:trajectory inference· 2 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:diffusion model· 1

Frequent Co-Authors

A Herman· 1 shared A Robichaud· 1 shared Adam David DurbiniD· 1 shared Alejandro Sweet-CorderoiD· 1 shared Anang A. ShelatiD· 1 shared Balakrishna KoneruiD· 1 shared C. Patrick ReynoldsiD· 1 shared Catarina D. CampbelliD· 1 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A Herman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

KRT7CreER Ferrets Enable Lineage Tracing of Ductal Epithelia and Pancreatic Remodeling

Yaling Yi, Yu Sun, Peipei Wu, Zheqing Hu, Yuhui Weng, Yuan Feng, Xiaoming Liu, Ziying Yan, Xingshen Sun, John F. Engelhardt

This study uses KRT7CreER ferrets to trace ductal epithelial lineage and pancreatic remodeling in health and cystic fibrosis.

bioRxiv · Oct 22, 2026 · PreprintPathology

MORPHE: Bridging Image Generation and Spatial Omics for Tissue Synthesis

Yuan Feng, Zachary Robers, Leyla Rasheed, Miao Yang, Shuo Wen, Kevin Lee, James Sohigian, Maria Brbić, John W. Hickey

MORPHE synthesizes biologically faithful tissue architecture from spatial-omics data, enabling reconstruction and extension of tissue context beyond experimental limitations.

bioRxiv · May 28, 2026 · PreprintSystems Biology

Tabular foundation model predicts alternative lengthening of telomeres (ALT) and identifies SMARCAL1 as a target in ALT-driven cancers

Declan Bennett, Monika Wierdl, S Chakraborty, Jordan Johnson, Victoria Akingbehin, Daniel Estevez-Prado, Yuan Feng, Janeala J. Morsby, John Harper, Mohammad Ali Mohammad Nezhady, M Pan, Nicole Ocasio-Martinez, Jerrel Lewis Catlett, TB Nations, Neekesh V. Dharia, , Lillian M. Guenther

The paper develops ALTitude, a machine learning model to predict ALT status from whole genome sequencing data, identifies SMARCAL1 as a therapeutic target in ALT-driven cancers.

bioRxiv · May 28, 2026 · PreprintCancer Biology

A Kmer-based paired-end read (KPR) de novo assembler and genotyper to genotype major histocompatibility complex class I (MHC-I) alleles for the dog

Yuan Feng, William H. Hildebrand, Stephen Mark Tompkins, Shaying Zhao

The paper develops a KPR tool for MHC-I genotyping in dogs using RNA-seq data, achieving 86% success rate and identifying 122 new alleles.

bioRxiv · Jul 15, 2020 · PreprintBioinformatics