Ziying Yan

This study uses KRT7CreER ferrets to trace ductal epithelial lineage and pancreatic remodeling in health and cystic fibrosis.

This study identifies KRT7+ cells in airway glands as multipotent progenitors that support development, homeostasis, and regeneration, with potential implications for cystic fibrosis therapies.

This paper identifies TBC1D23 as a host protein that binds AAVR and mediates endosome-to-TGN trafficking required for rAAV transduction.

This study identifies that the AAV2.5T capsid's VP1u region depends on GPR108 for transduction of human airway epithelium, and that doxorubicin enhances transduction by improving nuclear import.

This study identifies SLC35A1 as a host factor essential for rAAV transduction, showing its role in vector nuclear import across multiple AAV serotypes.

This study identifies host restriction factors critical for rAAV2.5T transduction of polarized human airway epithelium, revealing KIAA0319L's role in transduction but not internalization, and WDR63's role in transduction without involvement in internalization or nuclear entry.