BioinformaticsbioRxivPreprint
Pair-complete structural gating enables Pareto optimization of de novo cyclic peptides with preserved binding geometry and improved developability
Yuanchao Hou, Yixin Zhang, Zhuoyan Liu…·Shengwen Yang
This paper introduces RF-PepTune, a method that improves cyclic peptide design by preserving binding geometry while optimizing multiple properties, achieving higher success rates in structural and functional criteria.
DOI 10.64898/2026.09.24.754053