Pharmacology & ToxicologybioRxivPreprint
Overcoming Topology Bias and Cold-Start Limita-tions in Drug Repurposing: A Clinical-Outcome-Aligned LLM Framework
Ruihu Du, Mancheong FUNG, Yuanjia HU, Dongyang LIU
This paper introduces a framework that improves drug repurposing by aligning LLM reasoning with clinical outcomes, overcoming topology bias and cold-start limitations.
DOI 10.64898/2026.01.12.699148