Cancer BiologybioRxivPreprint
Cohesin constrains histone modification-driven chromatin dynamics
Takeshi Fujino, Yotaro Ochi, Susumu Goyama…·Toshio Kitamura
This study shows that mutations in Asxl1 and Stag2 cause dysregulation of histone modifications and chromatin structures, leading to aberrant gene upregulation and myelodysplastic syndromes.