Author
Gladstone Institutes
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Chao Wang, Li Fan, Rabia R. Khawaja…·Li Gan
This study shows that microglial NF-κB signaling drives tau spreading and toxicity in a mouse model of tauopathy, with inhibition reducing tau pathology and cognitive deficits.
Tara E. Tracy, Jesús Madero‐Pérez, Danielle L. Swaney…·Li Gan
The paper maps Tau interactomes in neurons using APEX and AP-MS to reveal activity-dependent interactions and FTD mutation effects on mitochondrial associations in neurodegenerative diseases.
Lihong Zhan, Li Fan, Lay Kodama…·Li Gan
The paper identifies a Csf1r-independent microglial subset in adult mice that exhibits progenitor-like features and is distinct from homeostatic microglia.
Faten A. Sayed, Lay Kodama, Joe C. Udeochu…·Li Gan
This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.
Lihong Zhan, Grietje Krabbe, Fei Du…·Li Gan
This study shows that adult microglia self-renew to restore homeostasis after ablation, with specific maturation programs and spatial organization.