Z. D. Nagel

This study applies active learning to improve variant interpretation for tumor genomes, showing better performance than traditional methods in predicting variant effects on cancer treatment.

This study identifies two molecular interaction points between NEIL1 and RPA using biophysical methods and shows that disrupting this interaction does not impair NEIL1's activity against oxidative DNA damage in vitro but reveals a role in nucleotide excision repair in vivo.

This study shows that long-term veliparib treatment leads to chromatin-bound PARP1 and upregulation of inflammatory genes in BRCA1 mutant cells, but not in BRCA1-complemented cells.

The paper evaluates XRCC1 expression and localization in triple negative breast cancer to assess BER defects and their correlation with DNA damage and repair capacity.