B. Li

Evidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology

This study shows cPLA2 overactivation is linked to synaptic loss and cognitive decline in Alzheimer's disease through increased eicosanoids and altered synaptic marker interactions.

Application of machine learning in a rodent malaria model for rapid, accurate, and consistent parasite counts

The paper develops a machine learning tool for automated parasite counting in rodent malaria models, achieving high accuracy and consistency across labs.

Quantifiable Blood TCR Repertoire Components Associated with Immune Aging

The paper identifies age-associated TCR repertoire components using a new computational framework and links them to immune aging and clinical outcomes.

Bioenergetic stress potentiates antimicrobial resistance and persistence

This study shows that bioenergetic stress from antibiotic treatment enhances antimicrobial resistance and persistence in E. coli through increased ROS, repair mechanisms, and stringent response activation.

Cloud-Connected Patch-Worn Auscultation Device for Chest Sound Monitoring

The paper describes a wearable device for chest sound monitoring that transmits 10-second recordings via Bluetooth-Low-Energy and includes noise reduction features.

FABP4-mediated lipid accumulation and lipolysis in tumor associated macrophages promote breast cancer metastasis

This study shows that FABP4 in tumor-associated macrophages promotes breast cancer metastasis by mediating lipid accumulation and lipolysis in response to unsaturated fatty acids.

Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via caspase BmICE

This paper identifies NbSPN14, a serine protease inhibitor secreted by Nosema bombycis, which inhibits host cell apoptosis by interacting with BmICE, providing insights into pathogen-host interactions.

Piximi - An Images to Discovery web tool for bioimages and beyond

Piximi provides a no-programming web tool for biological image analysis using deep learning, enabling rapid insights without installation or coding.

Effects of lysine and methionine on mRNA expression of candidate transcription factors by primary bovine mammary epithelial cells

This study examines how lysine and methionine deficiency affects mRNA expression of candidate transcription factors in bovine mammary epithelial cells, revealing differential impacts on gene expression and cell proliferation.

Targeting PRMT3 Impairs Methylation and Oligomerization of HSP60 to Boost Anti-Tumor Immunity by Activating cGAS/STING Signaling

This study identifies PRMT3 as a driver of immunotherapy resistance in HCC, showing that targeting it enhances anti-tumor immunity via cGAS/STING activation.

PRR adjuvants restrain high stability peptides presentation on APCs

This study shows adjuvants like MPLA and CpG reduce high-stability peptide presentation on APCs, shifting T-cell immunodominant epitope responses.

Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage

This paper develops a method to inhibit L-type CaV1 channels in neurons using opto-chemogenetic tools, showing acute and potent inhibition through membrane-assisted molecular linkage.

Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer

This paper develops humanized anti-FABP4 monoclonal antibodies that inhibit breast cancer tumor growth and metastasis by targeting FABP4's role in lipid metabolism.

High glucose treatment induced nuclei aggregation of microvascular endothelial cells via foxo1a-klf2a pathway

This study shows high glucose causes endothelial cell nuclei aggregation in zebrafish via foxo1a-klf2a pathway, linking it to microvascular complications.

Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis

Meta-transcriptomic analysis of companion animal infectomes reveals their diversity and potential roles in animal and human disease

The paper analyzes meta-transcriptomic data from companion animals to identify microbial communities and assess zoonotic risks.

A perivascular niche supports endometrial epithelial regeneration

This study identifies Nestin+ perivascular cells as contributors to endometrial epithelial regeneration through estrogen-stimulated suppression of Notch signaling.

Metabolic phenotyping of healthy and diseased human RPE cells

This study identifies nutrient utilization differences between healthy and diseased human RPE cells, showing reduced metabolic flexibility in SFD RPE and the impact of differentiation on nutrient use.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

Global heterogeneity of latitudinal patterns in herbivory between native and exotic plants

The paper quantifies global latitudinal herbivory gradients for native and exotic plants, finding native plants show a decline with latitude while exotic plants do not, mediated by herbivore guilds and climate factors.

Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal

This study shows noncaloric monosaccharides cause excessive angiogenesis in zebrafish by activating foxo1a-marcksl1a signaling, leading to ectopic tip cell formation.

Stress Granule Protein TZF1 Enhances Salt Stress Tolerance by Targeting ACA11 mRNA for Degradation in Arabidopsis

This study identifies TZF1 as a stress granule protein that enhances salt stress tolerance in Arabidopsis by degrading ACA11 mRNA, thereby upregulating salt tolerance genes.

Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability

This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.

Association of poultry vaccination with the interspecies transmission and molecular evolution of H5 subtype avian influenza virus

This study examines how poultry vaccination affects H5 avian influenza virus transmission and evolution, finding increased nonsynonymous divergence in vaccinated poultry lineages.

Cross-continental variation of herbivore resistance in a global plant invader

The paper examines genetic differentiation in herbivore resistance traits among native and introduced populations of Japanese knotweed across different regions.

Regulation of blood pressure by METTL3 via RUNX1b-eNOS pathway in endothelial cells

This study shows METTL3 reduces blood pressure by stabilizing RUNX1b mRNA via m6A modification, increasing eNOS expression in endothelial cells.

NS2B-D55E and NS2B-E65D Variations are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model

This study identifies NS2B-55 and NS2B-65 variations as responsible for differences in NS2B-NS3 protease activity between JEV genotype I and III using fluorogenic peptide assays.

Molecular Regulation of Invasive Protrusion Formation at the Mammalian Fusogenic Synapse

The paper identifies the spatiotemporal coordination of WAVE and N-WASP with actin-bundling proteins in invasive protrusion formation at the mammalian fusogenic synapse.

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

A dipteran parasite regulates 20E synthesis and antibacterial activity of the host for development through inducing host nitric oxide production

This study shows that a dipteran parasite increases host nitric oxide production to regulate 20E synthesis and antibacterial activity, supporting its development.