Rescuing AAV gene transfer from antibody neutralization with an IgG-degrading enzyme
A. Asokan, Z. Elmore, K. Simon, D. Oh, M. Fanous
This study shows that administering an IgG-degrading enzyme (IdeZ) can overcome pre-existing antibodies against AAV vectors, improving gene therapy efficacy in animal models.
bioRxiv · May 12, 2020 · PreprintImmunology