D. Oh

Antibody-conjugating nanogel (Conjugel) with two immune checkpoint inhibitors for enhanced cancer immunotherapy

This study develops a nanogel-based system that delivers two immune checkpoint inhibitors, enhancing cancer immunotherapy efficacy and reducing toxicity compared to traditional methods.

GPR84-Mediated Signal Transduction Promotes Brown Adipocyte Function

This study shows that GPR84 promotes brown adipocyte function by regulating mitochondrial calcium and respiration, with implications for metabolic disease treatment.

A virus-induced circular RNA maintains latent infection of Kaposi sarcoma herpesvirus

This study identifies a virus-induced circular RNA, hsa_circ_0001400, that promotes KSHV latency by inhibiting lytic replication and enhancing cell survival.

Probe the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

The paper investigates how EphA2 receptor clustering affects signaling efficiency by using substrates with controlled ligand mobility, finding that clustering increases phosphorylation and binding dwell time for signaling modules.

Rescuing AAV gene transfer from antibody neutralization with an IgG-degrading enzyme

This study shows that administering an IgG-degrading enzyme (IdeZ) can overcome pre-existing antibodies against AAV vectors, improving gene therapy efficacy in animal models.

TCR convergence in individuals treated with immune checkpoint inhibition for cancer

The paper compares TCR convergence detected by two sequencing platforms in cancer patients and finds Illumina-based sequencing shows higher convergence, which can be used to predict treatment response.

Force dependence of filopodia adhesion: involvement of myosin II and formins

This study investigates how forces affect filopodia adhesion, showing that myosin IIA and formins are essential for force-dependent adhesion and substrate preference.