K. Simon

A central protein complex essential for Invasionin Toxoplasma gondii

The paper identifies a central protein complex in Toxoplasma gondii essential for invasion, showing that disruption of this complex blocks rhoptry secretion and host cell invasion.

Mammals adjust diel activity across gradients of urbanization

The paper examines how eight mammal species adjust their daily activity patterns across urbanization gradients in ten U.S. cities, finding species-specific responses to environmental factors.

Effects of Hydroxychloroquine and Azithromycin on iPSC-derived Cardiomyocytes: Considerations for the Treatment of COVID-19 Patients

This study investigates the effects of HCQ and AZM on iPSC-derived cardiomyocytes, finding that their combination significantly increases cardiotoxicity and electrophysiological dysfunction.

Autophagy in T cells from aged donors is maintained by spermidine, and correlates with function and vaccine responses

This study shows that spermidine maintains autophagy in aged human T cells, improving vaccine responses by enhancing IFN-gamma secretion and T cell function.

Rescuing AAV gene transfer from antibody neutralization with an IgG-degrading enzyme

This study shows that administering an IgG-degrading enzyme (IdeZ) can overcome pre-existing antibodies against AAV vectors, improving gene therapy efficacy in animal models.

Anopheles stephensi as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian Plasmodium vivax and Plasmodium falciparum isolates

The paper assesses the susceptibility of Anopheles stephensi to Ethiopian Plasmodium vivax and P. falciparum isolates, finding high receptivity and potential for increased malaria transmission in the Horn of Africa.

Fenbendazole controls in vitro growth, virulence potential and animal infection in the Cryptococcusmodel

This study shows fenbendazole inhibits Cryptococcus growth in vitro and in mice, reduces virulence, and synergizes with amphotericin B.