Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia
Z. Mann, F. Lim, S. Verma, B. N. Nanavati, J. M. Davies, J. Begun, E. C. Hardeman, P. W. Gunning, D. Subramanyam, A. S. Yap, K. Duszyc
This study shows that pre-existing mechanical tension at adherens junctions impairs apoptotic extrusion in epithelia, and this effect can be reversed by reducing tension.
bioRxiv · Aug 31, 2023Cell Biology