Author

F. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:zebrafish· 1

Frequent Co-Authors

A. S. Yap· 2 shared K. Duszyc· 2 shared S. Verma· 2 shared A. M. Kane· 1 shared B. A. Leggett· 1 shared B. N. Nanavati· 1 shared B. Salik· 1 shared C. E. Bond· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

A. S. Yap

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia

Z. Mann, F. Lim, S. Verma, B. N. Nanavati, J. M. Davies, J. Begun, E. C. Hardeman, P. W. Gunning, D. Subramanyam, A. S. Yap, K. Duszyc

This study shows that pre-existing mechanical tension at adherens junctions impairs apoptotic extrusion in epithelia, and this effect can be reversed by reducing tension.

bioRxiv · Aug 31, 2023Cell Biology

Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia.

K. Duszyc, J. von Pein, D. Ramnath, D. Currin-Ross, S. Verma, F. Lim, M. J. Sweet, K. Schroder, A. S. Yap

The paper shows that apical extrusion prevents apoptosis from triggering inflammation in epithelia by eliminating apoptotic cells before they activate an IL-8-driven inflammatory response.

bioRxiv · Feb 12, 2023Cell Biology

Aspirin synergizes with regorafenib to reduce growth of colorectal cancer

C. Su, L. J. Fennell, C. E. Bond, A. M. Kane, G. Kerr, T. Jarde, D. Micati, R. M. Engel, W. H. Chan, S. Hlavca, S. Archer, P. J. McMurrick, H. Hammerlindl, F. Lim, B. Salik, , V. L. Whitehall

This study shows that aspirin and regorafenib together reduce colorectal cancer growth in preclinical models by inhibiting the PI3K-Akt-mTOR pathway and activating AMPK.

bioRxiv · Feb 11, 2022 · PreprintCancer Biology