TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming
W. Zhu, X. Xu, V. Nagarajan, J. Guo, Z. Pent, A. Zhang, J. Liu, M. J. Mattapallil, E. Jittayasothorn, M. Constantinides, R. Horai, Y. Belkaid, A. J. St. Leger, R. Caspi
This study identifies Vγ6 T cells as a major C. mast-responsive subset in the conjunctiva and shows that intrinsic TLR2 signaling drives metabolic reprogramming and IL-17A production.
bioRxiv · Apr 1, 2024Immunology