Metronomic therapy prevents emergence of drug resistance by maintaining the dynamic of intratumor heterogeneity.
M. Bondarenko, M. Le Grand, Y. Shaked, Z. Raviv, G. Chapuisat, C. Carrere, M.-P. Montero, M. Rossi, E. Pasquier, M. Carre, N. Andre
This study shows metronomic therapy better controls tumor heterogeneity than maximum-tolerated dose by leveraging drug-sensitive clones' suppressive effect on resistant ones through paracrine mechanisms.
bioRxiv · Jan 4, 2021 · PreprintCancer Biology