Cancer BiologybioRxivPreprint
Metronomic therapy prevents emergence of drug resistance by maintaining the dynamic of intratumor heterogeneity.
M. Bondarenko, M. Le Grand, Y. Shaked…·N. Andre
This study shows metronomic therapy better controls tumor heterogeneity than maximum-tolerated dose by leveraging drug-sensitive clones' suppressive effect on resistant ones through paracrine mechanisms.
DOI 10.1101/2021.01.04.425214