BioengineeringbioRxiv
Accelerated design of Escherichia coli genomes with reduced size using a whole-cell model and machine learning
I. M. Gherman, K. Sharma, J. P. Rees-Garbutt…·L. Marucci
The paper uses a whole-cell model and machine learning to design a reduced E. coli genome with 40% fewer genes, achieving 95% faster computation.
DOI 10.1016/j.cels.2025.101392