ImmunologybioRxivPreprint
The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway
A. Arnett, K. G. Moo, K. J. Flynn…·B. Khor
The paper identifies DCA as a CDK8 inhibitor that induces a tolerogenic immunophenotype in CD4+ T cells through a novel CDK8-GATA3-FOXP3 pathway, promoting Treg and Th2 differentiation while inhibiting Th1 and Th17.