Author

Zachary Mattiola

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Adam KlaissiD· 2 shared Matthias C. TruttmanniD· 2 shared Nicholas D. UrbaniD· 2 shared Sarah Tabler· 2 shared Asa W. Huffaker· 1 shared Ashley Scheutzow· 1 shared Benedict AbdoniD· 1 shared Janine KirsteiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Adam KlaissORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedFeb 4, 2026

HSP-1-Specific Nanobodies Alter Chaperone Function in vitro and in vivo

Nicholas D. Urban, Kunal Gharat, Zachary Mattiola…·Matthias C. Truttmann

This study develops two nanobodies that specifically target HSP-1, reducing its ATPase activity and protein folding capacity both in vitro and in vivo.

DOI 10.1016/j.jbc.2026.111238

C. elegansproteomics

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PhysiologybioRxivPreprintJan 14, 2025

Functionally diversified BiP orthologs control body growth, reproduction, stress resistance, aging, and ER-Phagy in Caenorhabditis elegans.

Nicholas D. Urban, Shannon M. Lacy, Kate M. Van Pelt…·Matthias C. Truttmann

This study shows how two HSP70 chaperones in C. elegans, HSP-3 and HSP-4, have distinct and overlapping roles in ER proteostasis, affecting growth, reproduction, stress resistance, aging, and ER-Phagy.

3 citations

C. elegansexperimental assay

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