Author

Zhen Ouyang

Chinese Academy of SciencesPrimary ORCID profile (0000-0003-0246-9809 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Zhen OuyangiD1 paper · Huazhong Agricultural University

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Genetics· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Liangxue LaiiD· 4 shared Yinghua YeiD· 3 shared Longquan Quan· 2 shared Quanjun ZhangiD· 2 shared Amar Deep SharmaiD· 1 shared Bentian Zhao· 1 shared Bingxiu Ma· 1 shared Chengcheng TangiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersImmunology

Liangxue LaiORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Development of a BM7G((TKO/hCD46/hCD55/hTHBD/hEPCR) Donor Pig with Endogenous Promoter-Driven Transgenes for Xenotransplantation

Cong Xia, Lian Meng, Bingxiu Ma, Hubei Yu, Renquan Zhang, Lijia Wen, X J Wang, Y ZHAO, Zhen Ouyang, Yinghua Ye, Xiner Feng, Han Wu, Liangxue Lai

This paper develops a seven-gene modified pig model with endogenous promoter-driven transgenes to improve xenograft survival in xenotransplantation.

Frontiers in Immunology · Jun 23, 2026Peer-reviewedImmunology

Derivation, Characterizations, and Applications of Rabbit Haploid Embryonic Stem Cells

Zhenpeng Zhuang, Manya Yu, Tao Cui, Tong Qiu, Yuanxi Yang, Longquan Quan, Lei Li, Quanjun Zhang, Yinghua Ye, Zhen Ouyang, Chengcheng Tang, Junwei Wang, Junjie Mao, Liangxue Lai

This study derives and characterizes rabbit haploid embryonic stem cells, showing their stable karyotype, pluripotency, and utility for genetic studies and disease modeling.

bioRxiv · Nov 5, 2025 · PreprintCell Biology

Hypoimmunogenic human motor neurons induced from iPSCs in vivo substantially ameliorate ALS disease in large animal models

Na Zhang, Yang Yang, Mengqi Chen, Qingjian Zou, Longquan Quan, Jiayuan Huang, Quanjun Zhang, Yu Zhao, Zhen Ouyang, Zhongtian Zhang, Yuning Song, Min Chen, Kun Zhang, Amar Deep Sharma, Michael Ott, , Liangxue Lai

Hypoimmunogenic human motor neurons induced from iPSCs in vivo reform neuromuscular junctions and ameliorate ALS disease in pig and rabbit models.

bioRxiv · Sep 3, 2025 · PreprintNeuroscience

CIRKO: A chemical-induced reversible gene knockout system for studying gene function in situ

Hui Shi, Qin Jin, Fangbing Chen, Zhen Ouyang, Shixue Gou, Xiaoyi Liu, Lei Li, Shuangshuang Mu, Chengdan Lai, Quanjun Zhang, Yinghua Ye, Kepin Wang, Liangxue Lai

The paper introduces a chemical-induced reversible gene knockout system (CIRKO) that allows for controlled inactivation and reactivation of genes in primary cells and animal models.

bioRxiv · Aug 31, 2022 · PreprintGenetics

Verified the effectiveness of AsCpf1 system in a variety of vertebrate species

Zhuo Li, Zhaoying Shi, Nana Fan, Yongqiang Chen, Jing Guo, Jingchun Wu, Hong Song, Shilong Chu, Kunlun Mo, Bentian Zhao, Zhen Ouyang, Dandan Tian, Shaoyang Zhao, Jieying Zhu, Jiekai Chen, , Duanqing Pei

The paper shows that AsCpf1 activity varies across vertebrate species due to temperature differences, as demonstrated by in vitro experiments.

bioRxiv · Feb 27, 2018 · PreprintDevelopmental Biology