BioinformaticsbioRxivPreprint
Filling the Missing Puzzle: Integrating Interaction and Evolutionary Information to Enhance Protein Fitness Prediction in Inverse Folding
Zhihao Wang, Zhongyang Zhang, Yanmei Yang…·Weifeng Li
This paper introduces zPolaron, a graph neural network for functional protein design that integrates structural, interaction, and evolutionary information, improving fitness prediction beyond structural compatibility.
DOI 10.64898/2026.10.05.756918