BioinformaticsbioRxivPreprint
A geometry-over-coevolution principle governs protein complex assembly in AlphaFold
Shuangjun Li, Zichun Mu, Chengfei Yan
This paper shows that geometry, not coevolution, primarily drives protein complex assembly in AlphaFold models, revealing a hierarchical mechanism for interface prediction.
DOI 10.64898/2026.04.03.716280