Cell BiologybioRxiv
Mapping Stress-Responsive Signaling Pathways Induced by Mitochondrial Proteostasis Perturbations
Nicole Madrazo, Zinia Khattar, Evan T. Powers…·R. Luke Wiseman
The paper identifies the integrated stress response (ISR) as the primary signaling pathway activated by mitochondrial proteostasis stress using gene set profiling in Perturb-seq datasets.