Cell BiologyAging CellPeer-reviewed
Blm10/PA200-activated 20S proteasomes promote α-synuclein degradation and bypass proteasome inhibition in Parkinson disease models
Tariq Tammam Ali, Anton Zhornyak, Madiha Mohieldin Merghani…·Gerhard H. Braus
This study shows that Blm10/PA200 activates 20S proteasomes to degrade α-synuclein and resist inhibition, improving proteostasis in Parkinson's disease models.