Author
Max Delbrück CenterORCID 0000-0001-5007-7442Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Shir Marom, I. DAYAN, Venkata Narasimha Kadali…·Ofer Shoshani
The paper investigates how extrachromosomal DNA (ecDNA) inheritance mechanisms influence cancer evolution through mitotic segregation and micronuclei formation.
Charlotte K. Brierley, Bon Ham Yip, Giulia Orlando…·Adam J. Mead
The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.
Lotte Brückner, Robin Xu, Jun Tang…·Anton George Henssen
This study shows that ecDNA mis-segregation leads to micronuclei formation, reduced oncogene transcription, and improved patient survival in neuroblastoma.
Jens Luebeck, Edwin Huang, Forrest Kim…·Vineet Bafna
AmpliconSuite identifies focal amplifications in cancer genomes, showing ecDNA has higher copy numbers and stronger oncogene enrichment compared to other amplification types.
Mădălina Giurgiu, Nadine Wittstruck, Elias Rodríguez-Fos…·Anton George Henssen
Decoil reconstructs complex extrachromosomal DNA structures from long-read sequencing data, improving resolution of ecDNA topology and heterogeneity in cancer.