Genetic & Genomic MedicinemedRxivPreprint
Author
Shouye Liu
The University of QueenslandORCID 0000-0001-5035-5887Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 40 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- GenomicsWorld Congress on Genetics Applied to Livestock Production (WCGALP)Peer-reviewed
Quantifying annotation-stratified pleiotropy and co-polygenicity between complex traits
Jiayi Qu, Tianjing Zhao, Tian Lin…·Hao Cheng
This paper introduces SBayesAPP, a Bayesian model that estimates annotation-stratified pleiotropy and co-polygenicity between complex traits using GWAS summary statistics, revealing cell-type-specific genetic correlations.
DOI 10.31274/wcgalp.24241 - Genetic & Genomic MedicinemedRxivPreprint
Transcriptional and translational genetic control in blood contributes significantly to complex trait heritability and polygenic prediction
Shouye Liu, Xiaoyu Qian, Yang Wu…·Jian Zeng
The paper evaluates the contribution of expression, splicing, and protein QTL in blood to SNP-based heritability and polygenic prediction across 27 traits, finding they capture significant portions of genetic variation.
1 citation - GeneticsNature GeneticsPeer-reviewed
Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
Zhili Zheng, Shouye Liu, Julia Sidorenko…·Jian Zeng
This paper introduces SBayesRC, a method that improves polygenic prediction of complex traits by integrating GWAS summary statistics with functional genomic annotations, showing significant accuracy gains across ancestries.
222 citationstop 1% - GeneticsThe American Journal of Human GeneticsPeer-reviewed
mBAT-combo: a more powerful test to detect gene-trait associations from GWAS data
Ang Li, Shouye Liu, Andrew Bakshi…·Jian Zeng
mBAT-combo improves gene-trait association detection in GWAS by accounting for SNP effect directions, revealing masking effects in complex traits.
63 citationstop 1%