Jerry W. Shay

This study shows that degrading tankyrase (TNKS) with PROTACs overcomes the limitations of catalytic inhibitors by preventing AXIN puncta formation and enhancing WNT/β-catenin pathway suppression in colorectal cancer.

This study identifies a novel tumor-predisposing syndrome linked to long telomeres through common and rare genetic variants.

This study examines the long-term behavioral effects of galactic cosmic radiation on female mice and evaluates the protective effects of an antioxidant compound.

The paper analyzes single-cell RNA-seq data to identify ACE2 expression patterns in human lung epithelial cells, finding high ACE2 expression in alveolar type II cells and co-expression with pathogen receptors.

The paper investigates t-loop dynamics during S phase, showing they unfold twice and persist throughout the phase.

This paper introduces a ddPCR method to measure mtDNA copy number at single-cell resolution, showing its ability to detect subtle changes in mtDNA content across aging and cancer.

The paper demonstrates that human telomerase holoenzymes have fast- and slow-acting catalytic sites that become inactive after two rounds of catalysis, and can be reactivated by intracellular factors.