Natalia Jura

The paper presents cryo-EM structures of the PI3Kα/KRas complex on lipid bilayers, revealing the conformational changes and molecular mechanisms of PI3Kα activation.

This study identifies a role for the MET juxtamembrane domain in accelerating kinase activation through an allosteric mechanism, with implications for MET-driven cancer therapies.

This study identifies CNPY4 as a sphingolipid-binding protein that regulates sphingolipid levels and distribution, impacting cholesterol homeostasis and cellular signaling.

The paper uses deep mutational scanning to analyze MET kinase domain mutations and their resistance to 11 inhibitors, identifying resistance and sensitizing mutations and improving prediction with a protein language model.

The paper identifies key residues in G3BPs that drive stress granule formation and gene expression changes under cellular stress, with G3BP2B showing specific roles in ER stress.

This study identifies ACE2 receptor polymorphisms that may influence susceptibility to SARS-CoV-2 by altering the interaction between ACE2 and the viral S-protein.

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.