NeurosciencebioRxivPreprint
Multiomic Evidence for a Unified Model of Alzheimer's Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown
Tom Paterson, Jennifer A. Rohrs, Timothy J. Hohman…·Cory C. Funk
4 citations
Author
Jennifer A. Rohrs
University of Southern CaliforniaORCID 0000-0001-5151-2135Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2018-2024 · peak 2/yrCo-Author Collaboration Network
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Recent·Most cited
- Systems BiologyiSciencePeer-reviewed
ERK activation in CAR T cells is amplified by CD28-mediated increase in CD3ζ phosphorylation
Jennifer A. Rohrs, Elizabeth L. Siegler, Pin Wang, Stacey D. Finley
The paper constructs a computational model of CAR T cell activation, showing CD28 enhances ERK activation by increasing CD3ζ phosphorylation kinetics.
38 citations - Systems BiologyBiophysical JournalPeer-reviewed
Computational model of chimeric antigen receptors explains site-specific phosphorylation kinetics
Jennifer A. Rohrs, Dongqing Zheng, Nicholas Alexander Graham…·Stacey D. Finley
The paper develops a computational model to explain site-specific phosphorylation kinetics of CARs using phospho-proteomic data and mechanistic modeling.
45 citations - Systems BiologybioRxivPreprint
Constructing predictive cancer systems biology models
Jennifer A. Rohrs, Sahak Z. Makaryan, Stacey D. Finley
This paper outlines an approach for parameterizing and validating systems biology models to create predictive tools that generate testable hypotheses and expand biological understanding.
3 citations