Author

Danielle C. Kirkey

Seattle Children's HospitalORCID 0000-0001-5176-9416Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Brandon HadlandiD· 1 shared Charles Grenfell MullighaniD· 1 shared Derek H. JanssensiD· 1 shared Derek Stirewalt· 1 shared Dominik Faerber· 1 shared Dominik J. OttoiD· 1 shared Florian BuettneriD· 1 shared Helong ZhaoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPathology

Brandon HadlandORCID

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2 papers

Recent·Most cited

PathologybioRxivPreprintOct 20, 2025

Cross-Species Morphology Learning Enables Nucleic Acid-Independent Detection of Live Mutant Blood Cells

Sarmad Ahmad Khan, Dominik Faerber, Danielle C. Kirkey…·Helong Zhao

This paper introduces a computer vision platform that detects live mutant blood cells with specific mutations using morphology recognition, without requiring nucleic acid sequencing.

DOI 10.1101/2025.10.20.682949

humanmouse

𝕏 PostBluesky

Cancer BiologyNature CommunicationsPeer-reviewedOct 29, 2024

KMT2A oncoproteins induce epigenetic resistance to targeted therapies

Derek H. Janssens, Melodie Duran, Dominik J. Otto…·Steven Henikoff

This study shows KMT2A oncoproteins drive lineage-switching and epigenetic resistance in leukemia by dynamically binding chromatin and persisting as ENL-marked lesions despite therapy.

18 citationstop 4%

humanChIP-seq

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