Alice Yu

This study shows oncogenic mutations disrupt lineage differentiation by altering DNA methylation, impairing stem cell reprogramming and differentiation while maintaining proliferation.

The paper introduces REMI, a graph-based method to reconstruct cell-cell interactions in lung adenocarcinoma by accounting for ligand-receptor dependencies, and validates its findings experimentally.

The paper identifies clinically relevant cell type interactions in the lung tumor microenvironment using RNA-seq data from sorted cell populations.