Ti‐Cheng Chang

This study identifies CCL2 as a chemokine that limits osteosarcoma metastasis via NK cell signaling in a mouse model.

This study investigates LOH caused by CRISPR-Cas9 DSBs, showing large-scale loss and mechanisms, and highlights risks when combined with end joining inhibition.

This study identifies uridine metabolism as a therapeutic target for chemo-resistant B-ALL by linking active signaling to uridine dependency and demonstrating DHODH inhibition as a promising treatment.

MitoEdit predicts optimal mtDNA base editing targets and bystander effects to reduce empirical testing.

The paper identifies differences in mtDNA mutation accumulation and selective pressures in pediatric leukemias using bulk and single-cell sequencing, linking these to functional heterogeneity among leukemic cells.

This paper establishes a diverse collection of preclinical models for pediatric solid tumors and demonstrates their utility in precision medicine trials and drug testing.

This paper creates a spatial cell atlas of neuroblastoma, revealing tumor heterogeneity through multi-omics data and identifying spatial compartmentalization and signaling patterns.