Cell BiologybioRxivPreprint
XIAP-mediated targeting of endolysosomes to stressed mitochondria occurs in a switch-like, global manner and results in autophagy-independent, sub-organelle level mitochondrial degradation
Tim Sen Wang, Isabelle Coppens, Nathan Ryan Brady, Anne Hamacher‐Brady
The paper shows XIAP mediates rapid, global endolysosome targeting to stressed mitochondria, leading to sub-organelle degradation independent of autophagy.