Xiaoli Wu

This study shows that ZMYND11 inhibits KMT2A to regulate neuronal development, and a mutation in ZMYND11 disrupts this interaction, leading to developmental and behavioral abnormalities.

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.