Author

Alexandre Zacharie Kadhim

National Institute for Health and Care ResearchORCID 0000-0001-5600-0411Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Amber M. Schedlbauer· 1 shared Amy Fong-Yuk PooniD· 1 shared Anik MuhuriiD· 1 shared Anna Lobanova· 1 shared David A. LewisiD· 1 shared Deema AlhusariiD· 1 shared Dong-Yeop LeeiD· 1 shared Emily LorenzeniD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperPathology

Amber M. Schedlbauer

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 12, 2026

Characterisation of Genetically-Derived Patient Clusters Highlights Genetic Heterogeneity of Inflammatory Bowel Disease

Fernando Lopez, Alexandre Zacharie Kadhim, Zachary Green…·James John Ashton

The paper uses GenePy scores and clustering to identify genetic clusters in IBD patients, finding NOD2 and NLRP1 as significant drivers with phenotypic associations.

DOI 10.64898/2026.10.05.754100

humanwhole-exome sequencing

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PathologyBiology Methods and ProtocolsPeer-reviewedJan 1, 2024

Unpacking Unstructured Data: A Pilot Study on Extracting Insights from Neuropathological Reports of Parkinson's Disease Patients using Large Language Models

Oleg V. Stroganov, Amber M. Schedlbauer, Emily Lorenzen…·Jill R. Glausier

This study uses large language models to structure unstructured neuropathological reports from Parkinson's disease patients, improving data consistency and enabling integration with clinical and genetic data.

20 citations

humanclinical cohort / trial

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GeneticsPLoS GeneticsPeer-reviewedDec 9, 2019

Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans

Naomi Shomer, Alexandre Zacharie Kadhim, Jennifer M. Grants…·Stefan Taubert

This study shows that MDT-15 and HIZR-1 cooperate to regulate metal detoxification and zinc storage in C. elegans, with partial conservation in mammals.

27 citations

C. elegansexperimental assay

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