Author

Chenchen Li

University of PennsylvaniaORCID 0000-0001-5627-7752Unclaimed ORCID profile · follow to get notified of new preprints

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Chenchen Li1 paper · University of Pennsylvania

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:multiome· 1

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Adam A. MoverleyiD· 1 shared Douglas C. WallaceiD· 1 shared Jian Yuan HuangiD· 1 shared Kevin A. JansseniD· 1 shared Kristen W. LynchiD· 1 shared Martin P. CarrolliD· 1 shared Mathieu Quesnel-VallièresiD· 1 shared Nicolas SkuliiD· 1 shared

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1 shared paperCancer Biology

Adam A. MoverleyORCID

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1 paper

Recent·Most cited

Cancer BiologyJournal of Clinical InvestigationPeer-reviewedMay 7, 2024

A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies

Xiaolei Liu, Sudhish A. Devadiga, Robert F. Stanley…·Peter S. Klein

This study shows that SRSF2 mutations disrupt mitochondrial mRNA splicing, impair complex I function, and increase mitophagy through a PINK1 splicing mechanism, identifying mitophagy as a therapeutic target in MDS and AML.

27 citations

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