Peter S. Klein

This study identifies that APC loss in colorectal cancer drives a β-CATENIN-independent fetal intestinal transcriptional program through YAP activation, leading to bistable stem cell states and enhanced tumorigenesis.

This paper identifies translation inhibitors that enable ex vivo expansion of human hematopoietic stem cells from umbilical cord blood while maintaining their function and enabling gene editing.

The paper investigates how chromatin accessibility and histone acetylation regulate the loss of competence to inductive signals during early development in Xenopus laevis.